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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Ricardo Mateo# | 291 | 2028-2042 | |
| 2 | Ronald Lowry* | 289 | 2011-2025 | |
| 3 | Ken Keddy | 277 | 2011-2027 | |
| 4 | Barry Wallace# | 261 | 2025-2041 | |
| 5 | Naomi Honma# | 247 | 2027-2041 | |
| 6 | Raúl Medina | 218 | 2014-2028 | |
| 7 | Andrés Hernández* | 217 | 2021-2036 | |
| 8 | Jin-song Zambrano# | 197 | 2035-2042 | |
| 9 | Chris Long* | 185 | 2014-2033 | |
| 10 | George Árias | 182 | 2014-2025 | |
| 11 | Leon Brunelle | 181 | 2016-2029 | |
| 12 | Pablo Ortíz# | 178 | 2028-2042 | |
| 13 | Royce Raines | 176 | 2019-2035 | |
| 14 | Rodrigo Vásquez# | 169 | 2030-2042 | |
| 15 | Mark Richardson | 152 | 2007-2017 | |
| 16 | Juan Carlos Gutiérrez# | 137 | 2029-2042 | |
| 17 | Steve Fergus | 135 | 2010-2016 | |
| 18 | Phil Anderson | 123 | 2014-2031 | |
| 19 | Bob Wade | 117 | 2026-2037 | |
| 20 | Hang-ki Fu# | 112 | 2037-2042 | |
| 21 | Héctor Castillo | 95 | 2007-2015 | |
| 22 | Brian O'Donnell | 93 | 2007-2013 | |
| 23 | Juan Hernández | 90 | 2018-2037 | |
| 24 | Theodore Boyd | 89 | 2007-2014 | |
| 24 | Bryan Cleveland | 89 | 2020-2036 | |
| 26 | Miguel Soto | 87 | 2007-2013 | |
| 27 | Nick Giles | 86 | 2017-2026 | |
| 28 | Bryant Hawkins | 85 | 2028-2039 | |
| 29 | Brian Coleman | 84 | 2020-2039 | |
| 30 | Eric Petersen | 83 | 2014-2021 | |
| 31 | Emílio Manuel | 82 | 2017-2032 | |
| 32 | António Gutiérrez# | 81 | 2036-2042 | |
| 32 | Torazo Kodama | 81 | 2024-2030 | |
| 34 | Alejandro Ortega | 79 | 2007-2013 | |
| 35 | Boyd Johnson | 76 | 2016-2023 | |
| 36 | Andrew Sterling | 73 | 2025-2035 | |
| 37 | Roberto Díaz | 72 | 2022-2035 | |
| 38 | Chris Holmes | 71 | 2010-2026 | |
| 39 | John Exley | 68 | 2018-2029 | |
| 39 | Thom Wright | 68 | 2017-2023 | |
| 41 | Henry Davis# | 67 | 2025-2040 | |
| 42 | Lonnie Dixon | 66 | 2018-2033 | |
| 43 | Augusto Quiñones | 65 | 2009-2016 | |
| 44 | José Pérez# | 64 | 2036-2042 | |
| 44 | Alfredo Vega | 64 | 2013-2023 | |
| 46 | Eric Nelson# | 62 | 2036-2042 | |
| 47 | Hikaru Arai | 61 | 2018-2033 | |
| 47 | Rick Coughlan | 61 | 2026-2037 | |
| 47 | Derrek Lollar | 61 | 2016-2024 | |
| 50 | José Alemán# | 60 | 2035-2042 | |
| 51 | Bob Ellerby# | 59 | 2033-2042 | |
| 51 | Jesús Reynoso | 59 | 2011-2018 | |
| 53 | Chih-tui Hsu# | 57 | 2039-2042 | |
| 53 | Jorge Velasco | 57 | 2012-2020 | |
| 55 | Javier Torres | 56 | 2024-2033 | |
| 56 | Gerald Contaldo# | 55 | 2038-2042 | |
| 57 | Naofumi Miyamoto# | 54 | 2038-2042 | |
| 58 | Sang-min O | 53 | 2026-2037 | |
| 59 | Tony Brown | 50 | 2016-2026 | |
| 59 | António Galló# | 50 | 2034-2042 | |
| 59 | Rod Young | 50 | 2012-2022 | |
| 62 | Steve Harris | 49 | 2011-2019 | |
| 62 | José Maldonado# | 49 | 2035-2042 | |
| 62 | José Rivera | 49 | 2010-2026 | |
| 65 | Dave Pacheco# | 48 | 2033-2042 | |
| 66 | Rubén Díaz | 47 | 2013-2024 | |
| 67 | Kurt Thornton | 46 | 2011-2018 | |
| 68 | George Riley | 45 | 2007-2020 | |
| 69 | Ken Schmidt# | 44 | 2036-2042 | |
| 70 | Marvin Gorrie# | 43 | 2035-2042 | |
| 70 | Shimei Nakamura | 43 | 2009-2011 | |
| 70 | Gil Sterling | 43 | 2017-2030 | |
| 70 | Víctor Torres# | 43 | 2032-2042 | |
| 74 | Tom Franks | 41 | 2007-2011 | |
| 74 | Mike Herr | 41 | 2013-2023 | |
| 74 | Juan Monasterio | 41 | 2011-2019 | |
| 74 | Kinfu Yawo# | 41 | 2037-2042 | |
| 78 | Christian Ramey | 40 | 2012-2025 | |
| 79 | Nathan Bolitho | 39 | 2012-2015 | |
| 79 | Manuel Santos | 39 | 2028-2039 | |
| 81 | Bartolo Chávez | 38 | 2019-2025 | |
| 81 | Rikiya Taketo | 38 | 2009-2013 | |
| 83 | Pablo Garza | 37 | 2022-2031 | |
| 83 | Mark Holmes | 37 | 2017-2026 | |
| 83 | Lee Kohler | 37 | 2009-2018 | |
| 86 | Yu-eh Bao# | 36 | 2039-2042 | |
| 86 | Luis Cedeño* | 36 | 2021-2039 | |
| 86 | Bud Hoffman | 36 | 2007-2018 | |
| 86 | Tom May# | 36 | 2031-2042 | |
| 90 | Mike Brown | 35 | 2007-2012 | |
| 90 | Hyung-oo Chu# | 35 | 2038-2042 | |
| 90 | David Teague | 35 | 2009-2016 | |
| 90 | Edison Terry | 35 | 2024-2034 | |
| 90 | Francisco Velasco | 35 | 2013-2016 | |
| 95 | Lowell Peterson | 34 | 2017-2022 | |
| 96 | Héctor Marroquín | 33 | 2026-2030 | |
| 97 | Lorenzo Aguilera# | 32 | 2034-2042 | |
| 97 | Yong-hong Gui# | 32 | 2040-2042 | |
| 97 | Ernest Mathis | 32 | 2007-2013 | |
| 97 | Manny Moreno# | 32 | 2033-2042 |
