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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Guillermo Fuentes | 178 | 2018-2034 | |
| 2 | Edgardo Medina | 152 | 2013-2034 | |
| 3 | Luis Valéncia | 150 | 2013-2028 | |
| 4 | Diego Feliciano# | 136 | 2024-2040 | |
| 5 | José Lópes | 116 | 2007-2014 | |
| 6 | Ánibal Martínez# | 100 | 2022-2040 | |
| 7 | Juan Morales# | 96 | 2033-2041 | |
| 8 | Héctor Marroquín | 88 | 2015-2036 | |
| 9 | Lorenzo Romero# | 84 | 2027-2041 | |
| 10 | Raúl Serrano# | 82 | 2030-2041 | |
| 11 | Raúl Quiñones | 81 | 2007-2016 | |
| 12 | Andrés Hernández | 80 | 2007-2020 | |
| 12 | Arturo Rodríguez# | 80 | 2034-2041 | |
| 14 | Orlando Reyes | 78 | 2013-2021 | |
| 15 | Edgardo Cortéz | 74 | 2007-2018 | |
| 16 | Roberto Cuevas | 73 | 2018-2027 | |
| 17 | José Maldonado | 72 | 2007-2022 | |
| 18 | Francisco Camacho | 70 | 2007-2017 | |
| 19 | Mario Menéndez# | 69 | 2025-2041 | |
| 20 | Carlos Villanueva | 67 | 2007-2018 | |
| 21 | Ángel Capata | 66 | 2018-2029 | |
| 21 | Carlos Rodríguez | 66 | 2007-2011 | |
| 23 | Orlando Martínez | 62 | 2016-2038 | |
| 24 | José González | 61 | 2007-2021 | |
| 25 | Juan Pérez | 59 | 2017-2025 | |
| 26 | Pedro Gallegos | 58 | 2009-2025 | |
| 27 | Roberto Caballero | 56 | 2007-2020 | |
| 28 | Felipe García# | 53 | 2024-2041 | |
| 29 | Enrique Méndez | 52 | 2019-2024 | |
| 29 | Javier Rodríguez# | 52 | 2029-2041 | |
| 31 | Gilberto Feliciano# | 50 | 2029-2041 | |
| 32 | Javier Muñóz | 49 | 2017-2023 | |
| 33 | Carlos Cavazos | 48 | 2014-2021 | |
| 34 | José González | 47 | 2013-2029 | |
| 34 | Gilberto Zamora# | 47 | 2026-2041 | |
| 36 | Jorge García# | 46 | 2029-2040 | |
| 36 | David Sánchez | 46 | 2012-2022 | |
| 38 | José Cedeño | 44 | 2007-2018 | |
| 38 | Takanori Sato | 44 | 2007-2009 | |
| 40 | Luis Martínez# | 41 | 2036-2041 | |
| 41 | Mario Vargas | 40 | 2007-2012 | |
| 42 | Salvador García# | 39 | 2032-2041 | |
| 43 | Pancho Guerrero | 36 | 2007-2013 | |
| 44 | Vicente Savellano | 35 | 2019-2023 | |
| 45 | José Castro# | 34 | 2037-2041 | |
| 45 | Antón Díaz | 34 | 2007-2017 | |
| 47 | Juan Silva | 33 | 2015-2024 | |
| 48 | Augusto Quiñones | 32 | 2007-2008 | |
| 49 | Sergio Mendoza# | 31 | 2027-2040 | |
| 50 | Manuel González# | 30 | 2035-2041 | |
| 51 | Francisco Martínez | 27 | 2015-2037 | |
| 51 | Francisco Soto# | 27 | 2035-2041 | |
| 53 | Francisco López# | 26 | 2031-2041 | |
| 53 | Rafael Soto | 26 | 2007-2012 | |
| 55 | Valentín Medrano | 25 | 2025-2040 | |
| 56 | Carlos De Jesús# | 24 | 2036-2041 | |
| 56 | Ramón Espinosa# | 24 | 2035-2040 | |
| 56 | Santiago Gutiérrez# | 24 | 2034-2041 | |
| 59 | Júlio Ramírez# | 23 | 2039-2041 | |
| 59 | Adrián Rivera | 23 | 2007-2012 | |
| 59 | Victorino Soto | 23 | 2015-2029 | |
| 59 | Fabián Vargas | 23 | 2007-2025 | |
| 63 | Raúl Durán# | 22 | 2035-2041 | |
| 63 | Pancho Díaz# | 22 | 2030-2040 | |
| 63 | Miguel Angel Estrada | 22 | 2007-2016 | |
| 63 | Miguel Núñez# | 22 | 2034-2041 | |
| 67 | Sergio Ferrer# | 21 | 2035-2041 | |
| 67 | Martín Rosas# | 21 | 2034-2041 | |
| 67 | Héctor Sosa | 21 | 2018-2026 | |
| 70 | Adrián Carrasco# | 20 | 2034-2041 | |
| 70 | Oliver Guzmán | 20 | 2007-2020 | |
| 70 | Alonso Montoya# | 20 | 2038-2041 | |
| 70 | Juan Otero | 20 | 2007-2008 | |
| 70 | Jorge Vargas | 20 | 2015-2024 | |
| 75 | Jesús Flores | 19 | 2028-2037 | |
| 75 | Gabriel Negrón | 19 | 2007-2010 | |
| 75 | Sixto Rodríguez | 19 | 2007-2012 | |
| 78 | Felipe López | 18 | 2022-2039 | |
| 79 | Ángel Fabián | 17 | 2007-2012 | |
| 79 | Robinson Sandoval | 17 | 2032-2035 | |
| 81 | Alejandro Alvarado | 16 | 2021-2028 | |
| 81 | Roberto Anguino# | 16 | 2033-2039 | |
| 81 | Juan Enríquez# | 16 | 2040-2041 | |
| 81 | Juan López# | 16 | 2032-2041 | |
| 81 | José Sánchez# | 16 | 2031-2041 | |
| 86 | Tony Aguilar# | 15 | 2035-2040 | |
| 86 | Gabriel Campos | 15 | 2028-2037 | |
| 86 | Ánibal Campos | 15 | 2008-2013 | |
| 86 | Mario Sánchez | 15 | 2013-2013 | |
| 90 | David Bell | 14 | 2008-2009 | |
| 90 | António Guzmán | 14 | 2007-2012 | |
| 90 | Roberto Luna | 14 | 2018-2027 | |
| 90 | Garrett Reid | 14 | 2018-2018 | |
| 90 | Marcos Román# | 14 | 2028-2033 | |
| 90 | Jorge Villa# | 14 | 2036-2041 | |
| 90 | Felipe Álvarez# | 14 | 2037-2041 | |
| 97 | Fernando Carrillo | 13 | 2007-2012 | |
| 97 | Reynaldo Martínez# | 13 | 2033-2041 | |
| 97 | Vicente Márquez# | 13 | 2037-2041 | |
| 97 | Carlos Puente# | 13 | 2038-2041 |
