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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Orlando Rodríguez# | 359 | 2021-2042 | |
| 2 | Jaime García | 191 | 2029-2035 | |
| 3 | Alfredo Reynoso | 135 | 2023-2033 | |
| 4 | Jesús Franco | 116 | 2007-2026 | |
| 5 | Roberto Ruíz | 102 | 2027-2036 | |
| 6 | Rafael Blanco# | 88 | 2033-2042 | |
| 7 | Reynaldo Sánchez | 83 | 2016-2028 | |
| 8 | Miguel Morales | 77 | 2007-2013 | |
| 9 | Gabriel Rocha | 65 | 2012-2016 | |
| 10 | Diego Vásquez | 58 | 2007-2013 | |
| 11 | Pedro Gallegos | 56 | 2007-2008 | |
| 12 | António Mendoza | 55 | 2007-2011 | |
| 12 | Luis Sepúlveda# | 55 | 2028-2042 | |
| 14 | Enrico Vera# | 49 | 2019-2042 | |
| 15 | Miguel Batses# | 48 | 2037-2042 | |
| 16 | José Acevedo# | 44 | 2040-2042 | |
| 16 | Raúl Rangel# | 44 | 2029-2042 | |
| 18 | Orlando Cruz# | 43 | 2034-2042 | |
| 19 | Héctor Alaniz | 36 | 2027-2031 | |
| 20 | Mauro Ortega | 31 | 2007-2017 | |
| 21 | Carlos Pacheco | 30 | 2014-2023 | |
| 22 | Robinson Sánchez# | 26 | 2036-2042 | |
| 23 | César Juárez | 22 | 2015-2016 | |
| 24 | Tony Hernández# | 21 | 2025-2042 | |
| 25 | Ángelo González | 20 | 2007-2008 | |
| 25 | José Guzmán# | 20 | 2029-2042 | |
| 25 | Pedro Núñez | 20 | 2007-2015 | |
| 25 | Cristián Ruíz# | 20 | 2028-2042 | |
| 29 | Raúl Sánchez | 19 | 2033-2041 | |
| 30 | Pedro Romero# | 14 | 2034-2041 | |
| 31 | António López# | 13 | 2037-2042 | |
| 32 | Robert Davis | 12 | 2007-2008 | |
| 32 | Gerardo Soto | 12 | 2015-2015 | |
| 34 | Salvador Alvarado# | 11 | 2031-2042 | |
| 34 | Héctor Martínez# | 11 | 2039-2042 | |
| 34 | Luis Salazar# | 11 | 2035-2042 | |
| 34 | Mario Sánchez# | 11 | 2039-2042 | |
| 38 | Adrián Morales# | 10 | 2039-2042 | |
| 39 | Roberto Avalos# | 9 | 2030-2042 | |
| 39 | José Cardenas# | 9 | 2034-2042 | |
| 39 | José Gutiérrez# | 9 | 2031-2042 | |
| 39 | Jesús Suárez | 9 | 2011-2016 | |
| 39 | José Velásquez# | 9 | 2041-2042 | |
| 44 | Javier Zúñiga# | 8 | 2032-2042 | |
| 45 | Jesús Correa# | 6 | 2034-2042 | |
| 45 | António De Los Santos# | 6 | 2042-2042 | |
| 45 | Albert Vázquez# | 6 | 2036-2042 | |
| 48 | Jorge Coreto | 5 | 2007-2017 | |
| 49 | Rafael Aragón | 4 | 2007-2013 | |
| 49 | Lúcio Hernández# | 4 | 2036-2041 | |
| 49 | Nelson Hernández | 4 | 2008-2014 | |
| 49 | Juan Manuel# | 4 | 2027-2042 | |
| 49 | Rodrigo Pérez# | 4 | 2040-2042 | |
| 49 | Gustavo Román# | 4 | 2040-2042 | |
| 55 | Armando Bermúdez# | 3 | 2035-2040 | |
| 55 | Gonzalo Delgado# | 3 | 2041-2042 | |
| 55 | Edgar González | 3 | 2007-2007 | |
| 55 | Manuel Magana# | 3 | 2037-2042 | |
| 55 | David Martínez# | 3 | 2038-2042 | |
| 55 | José Ruíz# | 3 | 2035-2042 | |
| 55 | Josh Strudwick | 3 | 2016-2016 | |
| 55 | Félix Vargas# | 3 | 2040-2042 | |
| 55 | Luis Vargas# | 3 | 2035-2042 | |
| 64 | Luis Miguel Adron# | 2 | 2031-2042 | |
| 64 | Carlos Molina# | 2 | 2027-2042 | |
| 64 | José Reyes# | 2 | 2032-2041 | |
| 64 | Sergio Rivera# | 2 | 2039-2042 | |
| 64 | José Sánchez# | 2 | 2033-2042 | |
| 69 | Ignacio Castaneda# | 1 | 2038-2039 | |
| 69 | Armando Cruz# | 1 | 2032-2042 | |
| 69 | Arturo García | 1 | 2018-2026 | |
| 69 | Gustavo Gonzáles# | 1 | 2037-2042 | |
| 69 | Carlos Herrera# | 1 | 2042-2042 | |
| 69 | Cristóbal Jiménez# | 1 | 2040-2041 | |
| 69 | Juan Paz# | 1 | 2042-2042 | |
| 69 | Carlos Pérez# | 1 | 2037-2042 | |
| 77 | Jesús Aimeda# | 0 | 2040-2042 | |
| 77 | Guillermo Balderas | 0 | 2008-2011 | |
| 77 | Francisco Cora# | 0 | 2030-2041 | |
| 77 | Arturo Días# | 0 | 2035-2042 | |
| 77 | Javier Farías# | 0 | 2032-2042 | |
| 77 | Adrián García# | 0 | 2036-2042 | |
| 77 | Ricardo García# | 0 | 2036-2041 | |
| 77 | Ricardo García# | 0 | 2040-2040 | |
| 77 | Juan González# | 0 | 2041-2042 | |
| 77 | Alejandro Gutiérrez# | 0 | 2041-2042 | |
| 77 | Carlos Hernández# | 0 | 2042-2042 | |
| 77 | Fernando León# | 0 | 2039-2042 | |
| 77 | Carlos López# | 0 | 2018-2042 | |
| 77 | Tomás Martínez# | 0 | 2039-2042 | |
| 77 | Roberto Morales# | 0 | 2030-2041 | |
| 77 | Dani Méndez# | 0 | 2035-2040 | |
| 77 | Javier Oliva# | 0 | 2037-2042 | |
| 77 | Juan Orozco# | 0 | 2038-2042 | |
| 77 | Mario Ortega# | 0 | 2030-2042 | |
| 77 | Mario Pérez# | 0 | 2031-2042 | |
| 77 | José Quintero | 0 | 2027-2031 | |
| 77 | Juan Rincón# | 0 | 2039-2040 | |
| 77 | Pedro Rivera# | 0 | 2038-2040 | |
| 77 | Jorge Rodríguez# | 0 | 2030-2041 |
