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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Jorge Ruíz# | 884 | 2025-2042 | |
| 2 | Juan Jose Montoya# | 486 | 2024-2042 | |
| 3 | Luis Cruz# | 467 | 2017-2042 | |
| 4 | José Rosas | 456 | 2015-2030 | |
| 5 | Enrico Vera# | 431 | 2019-2042 | |
| 6 | Carlos Gonzáles# | 429 | 2028-2042 | |
| 7 | Orlando Rodríguez# | 370 | 2021-2042 | |
| 8 | Carlos Romero | 366 | 2017-2034 | |
| 9 | Francisco Martínez | 347 | 2028-2038 | |
| 10 | José Hernández | 323 | 2020-2035 | |
| 11 | Jaime García | 273 | 2029-2035 | |
| 12 | Manny Cruz | 243 | 2007-2017 | |
| 13 | Luis Miguel Adron# | 209 | 2031-2042 | |
| 13 | José Pérez# | 209 | 2024-2035 | |
| 15 | Reynaldo Sánchez | 207 | 2016-2028 | |
| 16 | Jesús Franco | 203 | 2007-2026 | |
| 17 | Salvador Reyes | 189 | 2007-2020 | |
| 18 | Raúl Padilla# | 182 | 2028-2042 | |
| 19 | Marcos Disdier | 172 | 2007-2012 | |
| 20 | Esteban Germán# | 170 | 2030-2042 | |
| 21 | Anastasio Días | 168 | 2007-2026 | |
| 21 | Enrique Ortíz | 168 | 2007-2016 | |
| 21 | José Rea# | 168 | 2028-2042 | |
| 24 | Mario Ortega# | 166 | 2030-2042 | |
| 25 | Ramiro Fonseca | 165 | 2028-2036 | |
| 25 | Carlos Álvarez# | 165 | 2030-2042 | |
| 27 | Roberto Yánez# | 158 | 2030-2041 | |
| 28 | Félix Luna# | 157 | 2029-2042 | |
| 29 | Germán Barrera# | 156 | 2030-2042 | |
| 30 | Juan Manuel# | 151 | 2027-2042 | |
| 31 | Enrique Beltrán# | 150 | 2031-2042 | |
| 31 | Alfredo Reynoso | 150 | 2023-2033 | |
| 33 | Vicente Sáenz# | 148 | 2029-2042 | |
| 34 | Arturo Torres | 146 | 2007-2016 | |
| 35 | Manny Gonzáles# | 143 | 2028-2042 | |
| 36 | Miguel Morales | 142 | 2007-2013 | |
| 37 | Roberto Ruíz | 141 | 2027-2036 | |
| 37 | Juan Sánchez# | 141 | 2030-2042 | |
| 39 | Pablo Souza | 133 | 2017-2028 | |
| 40 | Manuel Rincón# | 132 | 2030-2041 | |
| 41 | Roberto Orralde# | 127 | 2030-2042 | |
| 42 | Rafael Francisco# | 126 | 2023-2042 | |
| 43 | Carlos Colón | 125 | 2007-2012 | |
| 44 | José Alsina | 124 | 2007-2023 | |
| 45 | Sergio Morán | 122 | 2007-2020 | |
| 46 | Jesús Ramos# | 119 | 2029-2042 | |
| 47 | David Hidalgo | 118 | 2007-2017 | |
| 48 | Luis Guzmán# | 117 | 2029-2042 | |
| 49 | Cristián Quiñones | 116 | 2010-2027 | |
| 49 | Miguel Soto | 116 | 2015-2026 | |
| 51 | Roberto Ortíz | 110 | 2017-2027 | |
| 52 | Jorge Díaz# | 108 | 2030-2042 | |
| 53 | Juan Manuel# | 104 | 2034-2042 | |
| 54 | Francisco Herrera# | 103 | 2030-2042 | |
| 55 | José Morán | 102 | 2014-2025 | |
| 56 | José Pérez | 101 | 2007-2010 | |
| 57 | Lorenzo Ortíz# | 100 | 2034-2042 | |
| 58 | Armando Cruz# | 99 | 2032-2042 | |
| 59 | Jaime García | 98 | 2007-2011 | |
| 60 | Roberto Torres# | 97 | 2031-2042 | |
| 61 | Diego Vásquez | 93 | 2007-2013 | |
| 62 | César Castillo | 92 | 2007-2011 | |
| 62 | Tony Hernández# | 92 | 2025-2042 | |
| 62 | Ángel Rivera# | 92 | 2035-2042 | |
| 65 | Alberto Gómez# | 91 | 2032-2042 | |
| 65 | Jesús Suárez | 91 | 2011-2016 | |
| 67 | Domingo López | 90 | 2029-2035 | |
| 67 | Andrés Vargas# | 90 | 2030-2042 | |
| 69 | Rafael Blanco# | 88 | 2033-2042 | |
| 69 | Gabriel Rocha | 88 | 2012-2016 | |
| 71 | Luis Miguel Hernández | 84 | 2007-2016 | |
| 71 | Mario Vázquez# | 84 | 2027-2042 | |
| 73 | Jorge Coreto | 81 | 2007-2017 | |
| 73 | Javier González# | 81 | 2030-2040 | |
| 73 | Carlos Lima# | 81 | 2039-2042 | |
| 73 | Bartolo Muñóz | 81 | 2007-2016 | |
| 77 | Manuel Sánchez# | 80 | 2035-2041 | |
| 78 | Eduardo Romero# | 79 | 2026-2042 | |
| 79 | Ángel Alvarado | 77 | 2007-2010 | |
| 79 | José Codne# | 77 | 2029-2042 | |
| 79 | Miguel Ibarra# | 77 | 2035-2042 | |
| 79 | Francisco Martínez | 77 | 2007-2016 | |
| 83 | Augusto Patrio# | 74 | 2032-2042 | |
| 84 | José Serrano | 73 | 2007-2014 | |
| 84 | Aurelio Zapata# | 73 | 2026-2042 | |
| 86 | César Jiménez# | 72 | 2029-2042 | |
| 86 | António Mendoza | 72 | 2007-2011 | |
| 86 | Sandro Torres | 72 | 2026-2036 | |
| 86 | Ángel Villanueva# | 72 | 2032-2042 | |
| 90 | Javier Cháves# | 69 | 2032-2042 | |
| 90 | Paco Mata# | 69 | 2033-2042 | |
| 90 | António Rivera# | 69 | 2034-2041 | |
| 93 | Israel Mecías# | 68 | 2038-2042 | |
| 94 | Sergio García | 67 | 2009-2017 | |
| 94 | Raúl Rangel# | 67 | 2029-2042 | |
| 96 | Rafael Gonzáles | 66 | 2007-2010 | |
| 96 | Júlio Hernández# | 66 | 2032-2042 | |
| 96 | Javier Madrid | 66 | 2007-2021 | |
| 96 | Tony Martínez | 66 | 2007-2014 | |
| 96 | Luis Sepúlveda# | 66 | 2028-2042 |
